From a post by 2k Elizabeth, a person who works for 2k Games:

hey guys,

first, let me say this. you DO NOT NEED TO USE THE INTERNET EVERY TIME YOU PLAY THIS GAME. it is only the first time.

second, you can uninstall and reinstall this game, and if, by chance, you have 2 computers you want to simultaneously play this game on, you also can do that.

if by some chance you are reinstalling this game without uninstalling it first, a lot, there is a chance you may have to call securom and get a key, or deactivate some older installations.

but if you upgrade your hardware next week, you'll still be able to play the game. if you revamp your system and need to reinstall bioshock, just uninstall it before you go through the overhaul, and then do your reinstall.

calling it "hardware fingerprinting" is a bit alarmist. we do not transmit any of your data to any companies.

really, the only people who will be concerned about any of these security measures are those who are rapidly putting bioshock on many pcs... if you use the game as you normally do, you won't notice this at all.

AWESOME!

I feel sorry for people who bought the game and don’t have an always-on internet connection. This protection means that the first time they go to play it, they’ll have to connect to the internet.

And I’ll now have to remember to uninstall the game next time I buy a new PC or rebuild my current one. And let’s hope the activation doesn’t fail randomly, because we know that never happens, especially on Windows Vista. Otherwise, I’ll be forced to call a third party (SecuROM) and plead my case. Wonderful!

And guess who doesn’t have to worry about any of these things? The people who pirated the game in the first place.

To top it off, she ends with basically saying if you aren’t doing anything wrong, you don’t have anything to worry about. Riiight. Since when is it up to game manufacturers to determine how many PCs I can install a game on?

You win, 2k Games! Truly you have conquered all video game pirating!